well my most accurate .22-250 load is a hornady B tip 55 grain head, and has killed a ton of critters out there and up close
but do only take head shots up close due to worries about it holding together due to speeds under 50 yrads

I have also killed a bunch of deer with same cal and load out to about 125 yrds on body shots, and out to 450 yrds on head shots
its a 1/2 inch group gun /load at 250 yrds
in right situations head shots to that range are almost sure things, but don't recommend this cal or load for deer, just yotes and smaller critters

smoked ground hogs out to 650 yrds with it too, messes them up even out there!